For random mobs, I carried 5 Appendage Crushers at all time. Of note, Yggralith Zero, the Global Nemesis, has a body part with a natural -3...his Heart which is exposed after breaking his chest plate. As long as nobody breaks it, you can do massive damage to him with only 2 Appendage Crushers, to get to the max -5 modifier, then stack other things like Ultrafauna Slayer.